A car bomb was detonated in the Sahat al-Hamam district of Syria's Latakia on Tuesday, according to state media.
Injuries were reported as footage carried on the state-run al-Ikhbariya news channel showed a large group of people milling around in a street while wreckage smouldered on the ground.
State news agency SANA reported that the driver of the vehicle, a Suzuki minivan, had been killed in the explosion, and that four other people had been wounded.
It reported that the authorities had dismantled another explosive device in the same location before the blast in the vehicle.
The Britain-based Syrian Observatory for Human Rights war monitor reported that five people had been injured in the explosion.